Is HMB Safe for Kidneys?

Beta-hydroxy beta-methylbutyrate—more commonly known as HMB—is a metabolite of leucine. Meaning, it’s created in our bodies as we metabolize leucine, which is a branched-chain amino acid (BCAA). Only 5% of the leucine in our bodies is converted into HMB, so it’s best to take a high-quality supplement with HMB present. In particular, a muscle health supplement like Muscle Health PLUS is a great way to give your body the nutrients and support it needs. 

Is HMB Hard on Kidneys? 

No, HMB is not hard on the kidneys. Your body metabolizes HMB by joining a coenzyme A molecule, followed by converting the resulting compound into beta-hydroxy-beta-methylglutaryl coenzyme A—the primary metabolite of HMB in the body. 

Image courtesy of PubMed Central

There is no evidence to suggest that HMB is hard on or damaging to the kidneys. In fact, studies have shown that HMB can be beneficial for kidney health, particularly for those with kidney disease. This is due to HMB’s ability to reduce inflammation and protect muscle tissue. 

HMB decreases muscle protein breakdown while increasing muscle protein synthesis—it operates on a dual-action mechanism. It is beneficial for both athletes and non-athletes, younger individuals and older individuals. Decreasing breakdown and increasing protein synthesis have been shown to increase strength, endurance, and recovery. 

For those who engage in regular athletic activity, HMB increases endurance, improves body composition, quickens muscle recovery, and increases strength gains. Additionally, HMB increases anaerobic capacity and reduces soreness following exercise. For older, aging adults, HMB improves daily function. It increases lean body mass and muscle strength, improves mobility, and reduces fatigue. It also decreases the loss of strength that’s associated with long-term bed rest, and can preserve muscle mass in those circumstances. 

Are There Any Negative Side Effects to HMB? 

No, there are no reported negative side effects to HMB. Some people in clinical trials reported gastrointestinal symptoms like stomach pain and constipation. However, these were rare circumstances and did not include the clinically studied version of HMB, myHMB®, which is the form of HMB we use in Muscle Health PLUS. 

Long-term HMB supplementation at 1.5-3 grams per day is generally considered safe for humans, at least for one year’s time. We always recommend you consult with your healthcare provider before starting new supplements or increasing dosage. There are no definitive studies of HMB effects on those who are pregnant or breastfeeding.

Is HMB Hard on Your Liver? 

No, there is no evidence to suggest that HMB is hard on your liver. In fact, HMB actually has a positive impact on liver health. A recent study showed that in those with liver disease, HMB restored muscle protein homeostasis. Additionally, HMB can improve energy metabolism and reduce inflammation, particularly in the case of cirrhosis and similar conditions. 

Should Seniors Take HMB? 

HMB has positive effects for seniors. In particular, it aids in muscle preservation and aids in daily function. It has anti-catabolic effects, which blunts strength loss and myofiber dimensions due to age. Catabolism is the metabolic breakdown of complex molecules like proteins or lipids, and anti-catabolic supplements, like HMB, work to decrease muscle and tissue loss during catabolism. Additionally, as we age, it’s expected that we experience cognitive decline. HMB can potentially reduce deficits in memory, attention, decision making, and more. 

In general, there are no standardized dosage requirements or recommendations for HMB. However, most studies have reported that 3 grams per day is the standard, and these recommendations do not change based on age demographics. When it comes to adding new supplements to your medication or supplement regimen, it’s important to discuss the best course of action with your healthcare provider. 

Conclusion

HMB is an amazing supplement for muscle health. myHMB® is made even more effective when it’s combined with other high-quality, clinically-studied ingredients like creatine monohydrate, Astragin® (this improves amino acid, peptide, folate, and glucosamine absorption, as well as protein synthesis in your muscles), BCAAs, and other essential amino acids. Muscle Health PLUS takes these ingredients and is clinically proven to reduce muscle breakdown, increase lean muscle mass, boost protein synthesis, and enhance strength. Whether you’re a regular athlete, someone who works out occasionally, or perhaps an older or less active adult wanting to support your muscles, Muscle Health PLUS is for you. Ready to give your muscles long-term support? Grab Muscle Health PLUS today!